Important

It is possible that the main title of the report Isaacs' Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• Continuous Muscle Fiber Activity Syndrome
• Neuromyotonia
• Quantal Squander
• Isaacs-Merten Syndrome
  

Disorder Subdivisions

• Neuromytonia, Generalized, Sporadic
• Neuromyotonia, Generalized, Familial
• Neuromyotonia, Focal

General Discussion

Isaacs' Syndrome is a peripheral motor neuron disorder characterized by muscular stiffness and cramping, particularly in the limbs. Continuous fine vibrating muscle movements (myokymia) can be seen. Muscle relaxation may be difficult especially after physical activity involving the particular muscle(s). These symptoms persist even during sleep.