Important

It is possible that the main title of the report Mannosidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

Lysosomal Alpha-D-Mannosidase Deficiency

Disorder Subdivisions

None

General Discussion

Mannosidosis is a genetic disorder characterized by a lysosomal enzyme deficiency resulting in progressive mental and physical deterioration. A deficiency of the enzyme alpha-D-mannosidase causes the symptoms of this disorder which can vary in severity. Symptoms of the most severe form may begin within the first year of life while a milder form may begin during juvenile or adult years.