Important

It is possible that the main title of the report Job Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synoyms

• HIE Syndrome
• Hyper-IgE Syndrome
• Hyperimmunoglobulin E Syndrome
• Hyperimmunoglobulin E-Recurrent
• Infection Syndrome
• Hyperimmunoglobulinemia E-Staphylococcal
• Job-Buckley Syndrome

Disorder Subdivision

None

General Discussion

Job Syndrome is an immunodeficiency syndrome characterized by recurrent bacterial (staphylococcal) infections, particularly of the skin, and markedly elevated IgE [Immunoglobulin E] levels.

Some patients have an autosomal dominant inheritance. The staphylococcal infection may involve the skin, lungs, joints and other sites. Some patients have coarse features; some are fair and redheaded. Decreased bone density and frequent fractures are common. Some present with neutrophils (a particular white blood cell) that doesn’t function normally. Signs of allergy, e. g. eczema, asthma and/or runny noses, are sometimes present as well. Treatment consists of intermittent or continuous antibiotics. Trimethoprim/sulfamethoxazole is particularly effective.