Important

It is possible that the main title of the report Hageman Factor Deficiency is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synoyms

• Factor XII Deficiency
• HAF Deficiency
• Hageman Trait

Disorder Subdivision

None

General Discussion

Hageman Factor Deficiency is a rare inherited blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the Hageman factor (Factor XII), a plasma protein (glycoprotein). Although it is thought that Factor XII is needed for blood clotting, when it is deficient, other blood clotting factors tend to compensate for its absence. This disorder is thought to be benign and usually presents no symptoms (asymptomatic); it is usually only accidentally discovered through pre-operative blood tests that are required by hospitals. Of substantial recent interest is the role of antibodies to Factor XII in recurrent pregnancy losses.