Important

It is possible that the main title of the report Hajdu Cheney Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synoyms

• Acroosteolysis with Osteoporosis and Changes in Skull and Mandible
• Arthro-Dento-Osteodysplasia
• Cheney Syndrome

Disorder Subdivision

None

General Discussion

Hajdu-Cheney Syndrome is a rare connective tissue disorder. Connective tissue is strong fibrous tissue that supports and joins other body tissues and parts. The most distinctive feature of individuals with this disorder is the appearance of ulcerating lesions on the palms of the hands and soles of the feet; this is accompanied by softening and destruction of bones (acroosteolysis). Abnormal development of bones, joints, and teeth also occurs. A decrease in bone mass and changes in the skull and jawbone are also features of this syndrome. The majority of cases are of unknown cause but multiple cases have been reported in families, suggesting autosomal dominant genetic transmission.