Laron Syndrome

Important

It is possible that the main title of the report Laron Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• GHBP
• GHR
• Growth Hormone Binding Protein Deficiency or Dysfunction
• Growth Hormone Receptor Deficiency or Dysfunction
• Laron Type Pituitary Dwarfism I
• LTD1
• Pituitary Dwarfism II
• Laron Dwarfism
  

Disorder Subdivisions

None

General Discussion

Laron syndrome (LTD1), a rare genetic disorder, is caused by the body's inability to use the growth hormone (GH) that it produces. The problem lies not in the production of growth hormone but rather in a defective GH-receptor. This defect prevents the proper binding of the GH molecule leaving high levels of unbound growth hormone in the plasma.

LTD1 is characterized by short stature, delayed bone age and, less frequently, blue eyes and hip degeneration as well as high levels of circulating growth hormone.

A second form of the disorder known as Laron syndrome type II (LTD2) shows typical clinical features of the Laron syndrome but is due to a defect in the biochemical processing of growth hormone after the hormone has been bound on the cell surface.