Important

It is possible that the main title of the report Korsakoff's Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name (s) and disorder subdivision (s) covered by this report.

Synonyms

• Binder Syndrome
• Maxillonasal Dysplasia
• Nasomaxillary Hypoplasia

Disorder Subdivisions

• None

General Discussion

Binder type maxillonasal dysplasia is a rare condition characterized by abnormal development (dysplasia) of the nasal and upper jaw (nasomaxillary) regions. Affected individuals typically have an unusually flat, underdeveloped midface (midfacial hypoplasia), with an abnormally short nose and flat nasal bridge; underdeveloped upper jaw; relatively protruding lower jaw (mandible); and/or a "reverse overbite" (class III malocclusion). In some reported cases, various additional abnormalities have also been present, particularly of the spinal column of the neck (cervical vertebral anomalies).

Many researchers suggest that Binder type maxillonasal dysplasia does not represent a distinct disease entity or syndrome, but, rather, is a nonspecific abnormality of the nasomaxillary regions. In most cases, the condition appears to occur randomly for unknown reasons (sporadically); rare familial cases have also been reported.